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Laboratory of Immunogenomics

About the Lab

 

We seek to understand how immune responses are regulated and to develop tools to engineer immunity

Disease happens when the immune system fails. Dysregulation of the immune system can result in an over-stimulated immune response as observed in allergy and autoimmune disorders, or a poor immune response that results in susceptibility to infection and cancer. We are using genomic technologies to dissect the molecular and cellular mechanisms that shape the immune response and determine how human genetics impacts an individual immunity. We are using this information to identify biomarkers and pathways that can be targeted to improve immunotherapies and vaccines.

Our laboratory mission is based on the scientific framework that disease occurs when the immune system fails. This is critical for the development of infection, cancer and autoimmunity. Our lab has two global research aims:

  1. Determine how antibody immune responses are regulated.
  2. Develop tools to engineer immunity

Leader


Dr. Todd Bradley is the Director of Immunogenomics at the Genomic Medicine Center in Children’s Mercy Kansas City. He is Assistant Professor of Pediatrics and Pathology and Laboratory Medicine at the University of Kansas Medical Center and the University of Missouri Kansas City Medical School. He is also a member of the University of Kansas Cancer Center.

Dr. Bradley came to Children’s Mercy from Duke University where he was Assistant Professor of Medicine and Director of Viral Genetic Analysis at the Human Vaccine Institute where he established genomics technologies to study the immune response and participated in the development of HIV-1 vaccine candidates. Dr. Bradley earned his PhD in Pathology and Laboratory Medicine from the University of Kansas Medical School where he worked at the Stowers Institute for Medical Research on regulatory mechanisms of gene expression and splicing.

Dr. Bradley is an expert in single-cell and cell population transcriptome and epigenomic study of the immune system, determining the B cell repertoire and antibody discovery.

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Headshot of Todd Bradley, PhD
Todd Bradley, PhD

Vice Chair of CMRI IBC, CMRI IBC; Director of Immunogenomics, Genomic Medicine Center; Associate Professor of Pediatrics, University of Missouri-Kansas City School of Medicine; Research Assistant Professor of Pediatrics, University of Kansas School of Medicine

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