About the Study

Diffuse Intrinsic Pontine Glioma (DIPG) and High-Grade Glioma (HGG): A study of Selinexor with Radiation Therapy

This study is for children and young adults: -Ages 12 months to 21 years old -With a new diagnosis of high-grade glioma (HGG) or diffuse intrinsic pontine glioma (DIPG). This study is being done to find the highest and safest dose of selinexor with radiation therapy.

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Full Study Name: ACNS1821 - A Phase 1/2 Trial of Selinexor (KPT-330) and Radiation Therapy in Newly-Diagnosed Pediatric Diffuse Intrinsic Pontine Glioma (DIPG) and High-Grade Glioma (HGG)