About the Study

Hypophosphatasia (HPP): A study of how the body reacts to asfotase alfa treatment over time

This study collects observational Standard of Care (SOC) data in patients currently receiving asfotase alfa for Hypophosphatasia or about to start treatment with asfotase alfa as determined by their doctor. Some blood samples deemed appropriate by the participant's doctor will be drawn at their regular clinic visits alongside any blood draws the participant may already have. This additional blood will be used for research purposes in the context of this observational study. The purpose of this research study is to do the following: - Collect information on patients who have HPP - Examine the body's immune response to the medication the participant takes for their disease - Examine how the participant's body reacts to their medication for HPP over time.

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Full Study Name: A Prospective Observational Sub-Study of the Global Hypophosphatasia Registry to Describe the Potential Risk of Immune-Mediated Loss of Pharmacological Effect of Asfotase Alfa in Participants with Hypophosphatasia