About the Study

Acute Lymphoblastic Leukemia or Lymphoma (ALL): A study on premedicating pediatric patients receiving PEG-asparaginase with antihistamines

Patients who are ages 1 to 26 may be eligible for this study. The purpose of this study is to see if taking an antihistamine (Benadryl® and either Pepcid® or Tagamet®) before PEG-asparaginase reduces allergic reactions. We also want to see if it reduces the need to switch to Erwinia asparaginase or another PEG-asparaginase substitute. In this study, we will document any side effects that occur within 30 days of treatment with PEG-asparaginase. We will also look at the level of asparaginase in patients' blood after each dose. We may also look at patients' genetic information to see how the body reacts to treatment with PEG-asparaginase.

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Full Study Name: Asparaginase Premedication, Hypersensitivity, and Therapeutic Drug Monitoring in Pediatric Patients with Acute Lymphoblastic Leukemia or Lymphoma