Update on the Role of Allergy in Pediatric Functional Abdominal Pain Disorders: A Clinical Perspective

Many studies show that a relationship exists between functional abdominal pain disorders (FAPDs) and food allergies. In this article, Craig Friesen, MD, Jennifer Colombo, MD, and Jennifer Schurman, PhD review current studies on the role of allergies in FAPDs.

They first report on the prevalence, noting that the majority of pediatric FAPD patients can identify at least one food known to worsen their symptoms. These patients often try to adjust their diets accordingly.

Within the biopsychosocial model, the authors next describe that allergens fall into the immunologic category. The role of inflammation is important since mast cells are often positioned at a connection point to the neurologic system. Both abdominal pain and food allergies are associated with psychologic dysfunction, but the complexity of triggers makes it challenging to identify symptom cause.

Next, authors break down risk factors between allergies and FAPDs, noting associations between pediatric allergic conditions which may later develop into FAPDs. They also detail data surrounding IgE-mediated allergies and non-IgE-mediated allergies.

Finally, they go into management, describing that standard allergy management may not be the answer to resolve an FAPD since allergens may be one of many triggers activating mast cells. While there may be overlap in medications or therapy, allergy testing is not likely to reliably identify triggers for FAPDs.

Read the publication.