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Acute Gastroenteritis: C. difficile

Clostridioides difficile Infection

Risk Factors

Testing

  • Antibiotic use within the past 10 weeks
  • Prolonged hospitalization (> 7 days) or < 72 hours from discharge following a prolonged hospitalization
  • Bowel surgery/GI tract manipulation within the past 30 days
  •  Ongoing immunosuppressant medication use including chemotherapy
  • Exposure to someone known to be colonized or known or suspected to have infection with C. difficile 
  •  C. difficile GDH/Toxin
    • Specimens from children less than 1 year will not be tested due to high incidence of C. difficile colonization in the age group
  • Non-liquid samples are tested only when toxic megacolon is suspected