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Anaphylaxis – Tryptase

  • Tryptase levels may be elevated in the setting of anaphylaxis. However, this lab is not rapidly available and is not useful in the immediate management of the patient.
  • It may be useful in case of recurrent anaphylaxis, especially if the trigger is unknown, or when the diagnosis of anaphylaxis is uncertain.
  • Importantly, a normal tryptase level does not rule out anaphylaxis. It is often normal in patients who develop anaphylaxis from foods.
  • If tryptase is obtained, it should be after 30 minutes but before 3 hours of event onset.

These pathways do not establish a standard of care to be followed in every case. It is recognized that each case is different, and those individuals involved in providing health care are expected to use their judgment in determining what is in the best interests of the patient based on the circumstances existing at the time. It is impossible to anticipate all possible situations that may exist and to prepare a pathway for each. Accordingly, these pathways should guide care with the understanding that departures from them may be required at times.