Hyperleukocytosis/Leukapheresis
Clinical Pathways promote evidence based, safe, and high-value care for patients by providing clinical recommendations and standard processes. They are developed by multidisciplinary committees of subject matter experts, informed by methodical review of available evidence and consensus among committee members.
Clinical Pathway:
- Hyperleukocytosis/Leukapheresis Algorithm
- Hyperleukocytosis/Leukapheresis Synopsis (provides care standards employed for this clinical pathway)
Inclusion and exclusion criteria:
- Inclusion:
- Newly diagnosed or relapsed acute leukemia AND WBC > 100K/µL
- Exclusion:
- Known diagnosis or high suspicion of acute promyelocytic leukemia (APML) or myelogenous leukemia (CML) in chronic phase
Committee members involved in the development:
• Amy Johnson, MD, MBA | Hematology/Oncology/BMT | Committee Co-Chair
• Meagan Vacek, DO| Hematology/Oncology/BMT | Committee Co-Chair
• Keith August, MD, MS| Hematology/Oncology/BMT | Committee Member
• Cherie Burroughs-Scanlon, RN, BSN, CPN | Apheresis Program | Committee Member
• Lejla Music Aplenc, MD | Pathology and Laboratory Medicine | Committee Member
• Jay Rilinger, MD | Critical Care Medicine | Committee Member
• Alyssa Stoner, MS, DO | Critical Care Medicine | Committee Member
• Nikki Wood, DO | Hematology/Oncology/BMT, Apheresis Program | Committee Member
EBP Committee Members:
• Todd Glenski, MD, MSHA, FASA | Anesthesiology, Evidence Based Practice
• Megan Gripka, MT (ASCP) SM | Evidence Based Practice
Publication dates:
• Finalized date: 11/2023
• Next expected revision date: 11/2026
If you have any questions regarding this content or identify a broken link, please email evidencebasedpractice@cmh.edu.
These pathways do not establish a standard of care to be followed in every case. It is recognized that each case is different, and those individuals involved in providing health care are expected to use their judgment in determining what is in the best interests of the patient based on the circumstances existing at the time. It is impossible to anticipate all possible situations that may exist and to prepare a pathway for each. Accordingly, these pathways should guide care with the understanding that departures from them may be required at times.