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Colectomy for Familial Adenomatous Polyposis (FAP): A study of tissue samples to understand bacteria in the gut
This study is currently enrolling patients who: • Are ages 7 to 20 years • Have been diagnosed with Familial Adenomatous Polyposis • Have been referred to colectomy within 12 months of surveillance colonoscopy...
This study is currently enrolling patients who: • Are ages 7 to 20 years • Have been diagnosed with Familial Adenomatous Polyposis • Have been referred to colectomy within 12 months of surveillance colonoscopy Familial Adenomatous Polyposis (FAP) is an inherited syndrome where polyps develop in the gut and will become cancerous. The purpose of this research study is to learn more about the relationship between bacteria in the gut and polyps. Being in this study involves the participant providing a stool sample and a blood sample. The parent/guardian will also give the study team permission to take tissue samples from their child's colon once it has been removed.
Colonoscopy with or without Polyposis: Tissue samples collected for research on cancer prevention and treatment
This study is currently enrolling patients who: • Are ages 1 month to 21 years • Have been diagnosed with polyposis, either clinically or through genetic testing with adenomas found on colonoscopy...
This study is currently enrolling patients who: • Are ages 1 month to 21 years • Have been diagnosed with polyposis, either clinically or through genetic testing with adenomas found on colonoscopy The main purpose of this study is to use normal tissues (not polyps) and non-normal tissues (polyps) to test candidate drugs or compounds against and ensure there is not significant toxicity to these normal cells. A study participant will have biopsies of tissue collected from different locations in their intestinal tract. The tissues will be stored in a way that allows cell to grow and multiply. The cell lines that potentially grow will be used to test the toxicity of the drugs or compounds that are being tested to see if they possibly help tissue affected by polyposis.